The Weizmann Institute is an internationally acclaimed basic research institute specializing in multidisciplinary areas in the exact and life sciences.
The Structural Proteomics Unit (SPU) within the Weizmann Institute of Science provides service, consultation, and guidance to scientists at any stage along the pipeline from gene to structure. The SPU implements state-of-the-art technologies for challenging scientific questions and offers various services, including protein production, purification, and crystallization screening. Weizmann’s Electron Microscope (EM) unit offers cryo-STEM, cryo-TEM imaging, and tomography.
The Weizmann Institute is one of the world’s leading multidisciplinary research institutions. Prof. Ada Yonath from the Department of Chemical and Structural Biology received the Nobel Prize in Chemistry in 2009 for deciphering the structure of the ribosome.
ISPC is currently available for limited remote access due to COVID-19 restrictions. For information on the availability of specific technologies, view the Technology Availability List or contact support@instruct-eric.eu. Please check here regularly for updates.
How to find us
The Weizmann Institute campus is located in Rehovot, near Tel Aviv. For information about travel to the Institute and accommodation, click here.
Protein production in bacteria, baculovirus, and mammalian cells. Proteins are typically purified following a standard 3 step protocol which includes: affinity capture, ion exchange and size exclusion. Specific techniques can be employed depending on the protein, the experimental requirements, tags and yields. Removal of tags with TEV protease can be employed.
View All Protein Production at Instruct
CryoSTEM and CryoTEM tomography on a Tecnai F20 with Quantum/K2 camera and BF/DF/HAADF STEM detectors.
Also room temperature STEM tomography of thick plastic sections.
Crystallisation screening: Utilizing the sitting and hanging drop by vapor diffusion methods for crystallising soluble proteins, using the Mosquito, and LCP Mosquito crystallisation robots.
