A Wellcome Trust-funded postdoctoral position is available immediately in the laboratory of Professor Laurence Pearl FRS in the MRC Genome Damage and Stability Centre at Sussex University, to study the structural basis for client protein recruitment and activation by the Hsp90 molecular chaperone system. We are very well equipped for all aspects of modern structural biology, with state-of-the-art laboratories for molecular biology, recombinant expression in bacterial and eukaryotic systems, biochemistry, biophysics and X-ray crystallography. Excellent synchrotron access (~2 days/month) is available through rolling beam allocation programmes at Diamond and ESRF.
Applicants must have a PhD, and experience in recombinant expression and protein purification. Experience of crystallisation and X-ray crystallography would be an advantage. Information on our previous work in this field can be found at by searching PubMed (pearl [au] and hsp90).
The postholder will be responsible for expression, purification, crystallization and structural analysis of protein complexes involving Hsp90, co-chaperones and client proteins that depend on Hsp90 for their biological function.
Informal enquiries can be made to Professor PearlLaurence.pearl@sussex.ac.uk.
