15-Jul-2022
The Crystallisation Core Facility at BIOCEV has greatly improved its screening equipment by installation of the SONICC instrument (Formulatrix). SONICC is using Second Harmonic Generation (SHG) and Ultraviolet Two-Photon Excited Fluorescence (UV-TPEF) in a completely automated imager to quickly image high throughput crystallisation plates and positively identify protein crystals.
SONICC is connected to the current RI1000 crystallisation hotel and is able to detect even extremely thin crystals, microcrystals <1 μm, and crystals obscured in birefringent LCP.
In addition, a new quadrupole time of flight mass spectrometer timsTOF SCP from Bruker Daltonics is now installed in the Structural Mass Spectrometry core facility of CMS. The instrument provides extremely high speed and sensitivity to tackle proteomes of single cells or post-translational modifications in a few cells.
The trapped ion mobility spectrometry (TIMS) device accumulates and concentrates ions of a given mass and mobility, enabling a unique increase in sensitivity and speed. Besides single cell proteomics, the new mass spectrometer allows highly sensitive identification and quantification of peptides and proteins.
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